作者
Konrad Gabrusiewicz, Benjamin Rodriguez, Jun Wei, Yuuri Hashimoto, Luke M Healy, Sourindra N Maiti, Ginu Thomas, Shouhao Zhou, Qianghu Wang, Ahmed Elakkad, Brandon D Liebelt, Nasser K Yaghi, Ravesanker Ezhilarasan, Neal Huang, Jeffrey S Weinberg, Sujit S Prabhu, Ganesh Rao, Raymond Sawaya, Lauren A Langford, Janet M Bruner, Gregory N Fuller, Amit Bar-Or, Wei Li, Rivka R Colen, Michael A Curran, Krishna P Bhat, Jack P Antel, Laurence J Cooper, Erik P Sulman, Amy B Heimberger
发表日期
2016/2/2
期刊
JCI insight
卷号
1
期号
2
出版商
American Society for Clinical Investigation
简介
Glioblastomas are highly infiltrated by diverse immune cells, including microglia, macrophages, and myeloid-derived suppressor cells (MDSCs). Understanding the mechanisms by which glioblastoma-associated myeloid cells (GAMs) undergo metamorphosis into tumor-supportive cells, characterizing the heterogeneity of immune cell phenotypes within glioblastoma subtypes, and discovering new targets can help the design of new efficient immunotherapies. In this study, we performed a comprehensive battery of immune phenotyping, whole-genome microarray analysis, and microRNA expression profiling of GAMs with matched blood monocytes, healthy donor monocytes, normal brain microglia, nonpolarized M0 macrophages, and polarized M1, M2a, M2c macrophages. Glioblastoma patients had an elevated number of monocytes relative to healthy donors. Among CD11b+ cells, microglia and MDSCs constituted …
学术搜索中的文章
K Gabrusiewicz, B Rodriguez, J Wei, Y Hashimoto… - JCI insight, 2016