作者
Egon A Ozer, Lacy M Simons, Olubusuyi M Adewumi, Adeola A Fowotade, Ewean C Omoruyi, Johnson A Adeniji, Oluseyi A Olayinka, Taylor J Dean, Janet Zayas, Pavan P Bhimalli, Michelle K Ash, Almoustapha I Maiga, Anou M Somboro, Mamoudou Maiga, Adam Godzik, Jeffrey R Schneider, João I Mamede, Babafemi O Taiwo, Judd F Hultquist, Ramon Lorenzo-Redondo
发表日期
2022/2/3
期刊
Nature communications
卷号
13
期号
1
页码范围
688
出版商
Nature Publishing Group UK
简介
Disparities in SARS-CoV-2 genomic surveillance have limited our understanding of the viral population dynamics and may delay identification of globally important variants. Despite being the most populated country in Africa, Nigeria has remained critically under sampled. Here, we report sequences from 378 SARS-CoV-2 isolates collected in Oyo State, Nigeria between July 2020 and August 2021. In early 2021, most isolates belonged to the Alpha “variant of concern” (VOC) or the Eta lineage. Eta outcompeted Alpha in Nigeria and across West Africa, persisting in the region even after expansion of an otherwise rare Delta sub-lineage. Spike protein from the Eta variant conferred increased infectivity and decreased neutralization by convalescent sera in vitro. Phylodynamic reconstructions suggest that Eta originated in West Africa before spreading globally and represented a VOC in early 2021. These results …
学术搜索中的文章
EA Ozer, LM Simons, OM Adewumi, AA Fowotade… - Nature communications, 2022