作者
Louise RA Olde Nordkamp, Reinoud E Knops, Gust H Bardy, Yuri Blaauw, Lucas VA Boersma, Johannes S Bos, Peter Paul HM Delnoy, Pascal FHM van Dessel, Antoine HG Driessen, Joris R de Groot, Jean Paul R Herrman, Luc JLM Jordaens, Kirsten M Kooiman, Alexander H Maass, Mathias Meine, Yuka Mizusawa, Sander G Molhoek, Jurjen van Opstal, Jan GP Tijssen, Arthur AM Wilde
发表日期
2012/5/1
期刊
American heart journal
卷号
163
期号
5
页码范围
753-760. e2
出版商
Mosby
简介
BACKGROUND
Implantable cardioverter-defibrillators (ICDs) are widely used to prevent fatal outcomes associated with life-threatening arrhythmic episodes in a variety of cardiac diseases. These ICDs rely on transvenous leads for cardiac sensing and defibrillation. A new entirely subcutaneous ICD overcomes problems associated with transvenous leads. However, the role of the subcutaneous ICD as an adjunctive or primary therapy in patients at risk for sudden cardiac death is unclear.
STUDY DESIGN
The PRAETORIAN trial is an investigator-initiated, randomized, controlled, multicenter, prospective 2-arm trial that outlines the advantages and disadvantages of the subcutaneous ICD. Patients with a class I or IIa indication for ICD therapy without an indication for bradypacing or tachypacing are included. A total of 700 patients are randomized to either the subcutaneous or transvenous ICD (1:1). The study is …
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