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Objective: Circumcision is the most frequently performed surgery in neonates and infants across the globe. The objective of this study was to assess the effectiveness of circumcision performed by Plastibell method by means of its safety and complications in neonates and infants. Methods: This prospective study was carried out in the department of surgical sciences, Baqai medical university on 480 male neonates and infants who were circumcised with Plastibell technique during January 2017 to November 2019. Data were collected on a set proforma indicating age of the patient, Plastibell size, time required by the device to detach and complications. Children were divided into two arms; neonates (0 to 4 weeks) and infants (5weeks to 1year). On discharge parents were instructed about the care of the device and were asked to follow up on day 3 and on day of detachment of the Plastibell. Results: During our study …