作者
CM López Fontana, Leila Ester Zyla, Flavia Eliana Santiano, Corina Verónica Sasso, Fernando Darío Cuello-Carrión, V Pistone Creydt, Mariel Andrea Fanelli, Ruben Walter Caron
发表日期
2017/6/1
期刊
Histochemistry and cell biology
卷号
147
期号
6
页码范围
759-769
出版商
Springer Berlin Heidelberg
简介
Experimental hypothyroidism retards mammary carcinogenesis promoting apoptosis of tumor cells. β-catenin plays a critical role in cell adhesion and intracellular signaling pathways conditioning the prognosis of breast cancer. However, the mechanistic connections associated with the expression of β-catenin in thyroid status and breast cancer are not known. Therefore, we studied the relationship between the expression and localization of β-catenin and apoptosis in mammary tumors induced by 7,12-dimethylbenz(a)anthracene (DMBA) in hypothyroid (Hypot) and euthyroid (EUT) rats. Female Sprague Dawley rats were treated with a dose of DMBA (15 mg/rat) at 55 days of age and were then divided into two groups: HypoT (0.01% 6-N-propyl-2-thiouracil in drinking water, n = 54) and EUT (untreated control, n = 43). Latency, incidence and progression of tumors were determined. At sacrifice, tumors …
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CM López Fontana, LE Zyla, FE Santiano, CV Sasso… - Histochemistry and cell biology, 2017