作者
Fiorella Campo Verde Arboccó, Corina V Sasso, Esteban A Actis, Rubén W Carón, María Belén Hapon, Graciela A Jahn
发表日期
2016/1/5
期刊
Molecular and cellular endocrinology
卷号
419
页码范围
18-28
出版商
Elsevier
简介
Thyroid diseases have deleterious effects on lactation, litter growth and survival, and hinder the suckling-induced hormone release, leading in the case of hyperthyroidism, to premature mammary involution. To determine the effects of hypothyroidism (HypoT) on late lactation, we analyzed the effect of chronic 6-propyl-2-thiouracil (PTU)-induced HypoT on mammary histology and the expression of members of the JAK/STAT/SOCS signaling pathway, milk proteins, prolactin (PRLR), estrogen (ER), progesterone (PR) and thyroid hormone (TR) receptors, markers of involution (such as stat3, lif, bcl2, BAX and PARP) on lactation (L) day 21. HypoT mothers showed increased histological markers of involution compared with control rats, such as adipose/epithelial ratio, inactive alveoli, picnotic nuclei and numerous detached apoptotic cells within the alveolar lumina. We also found decreased PRLR, β-casein and α …
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FCV Arboccó, CV Sasso, EA Actis, RW Carón… - Molecular and cellular endocrinology, 2016