作者
Dagmara McGuinness, Liane M McGlynn, Paul CD Johnson, Alan MacIntyre, G David Batty, Harry Burns, Jonathan Cavanagh, Kevin A Deans, Ian Ford, Alex McConnachie, Agnes McGinty, Jennifer S McLean, Keith Millar, Chris J Packard, Naveed A Sattar, Carol Tannahill, Yoga N Velupillai, Paul G Shiels
发表日期
2012/2/1
期刊
International Journal of Epidemiology
卷号
41
期号
1
页码范围
151-160
出版商
Oxford University Press
简介
Background Epigenetic programming and epigenetic mechanisms driven by environmental factors are thought to play an important role in human health and ageing. Global DNA methylation has been postulated as an epigenetic marker for epidemiological studies as it is reflective of changes in gene expression linked to disease. How epigenetic mechanisms are affected by psychological, sociological and biological determinants of health still remains unclear. The aim of this study was to investigate the relationship between socio-economic and lifestyle factors and epigenetic status, as measured by global DNA methylation content, in the pSoBid cohort, which is characterized by an extreme socio-economic and health gradient.
Methods DNA was extracted from peripheral blood leukocytes using the Maxwell® 16 System and Maxwell® 16 Blood DNA Purification kit (Promega, UK). Global DNA …
学术搜索中的文章
D McGuinness, LM McGlynn, PCD Johnson… - International journal of epidemiology, 2012