作者
Nicholas J Timpson, Nita G Forouhi, Marie-Jo Brion, Roger M Harbord, Derek G Cook, Paul Johnson, Alex McConnachie, Richard W Morris, Santiago Rodriguez, Jian'an Luan, Shah Ebrahim, Sandosh Padmanabhan, Graham Watt, K Richard Bruckdorfer, Nicholas J Wareham, Peter H Whincup, Steve Chanock, Naveed Sattar, Debbie A Lawlor, George Davey Smith
发表日期
2010/8/1
期刊
The American journal of clinical nutrition
卷号
92
期号
2
页码范围
375-382
出版商
American Society for Nutrition
简介
Background:l-Ascorbic acid is an essential part of the human diet and has been associated with a wide range of chronic complex diseases, including cardiovascular outcomes. To date, there are no confirmed genetic correlates of circulating concentrations of l-ascorbic acid.
Objective: We aimed to confirm the existence of an association between common variation at the SLC23A1 gene locus and circulating concentrations of l-ascorbic acid.
Design: We used a 2-stage design, which included a discovery cohort (the British Women’s Heart and Health Study), a series of follow-up cohorts, and meta-analysis (totaling 15,087 participants) to assess the relation between variation at SLC23A1 and circulating concentrations of l-ascorbic acid.
Results: In the discovery cohort, variation at rs33972313 was associated with a reduction in circulating concentrations of l-ascorbic acid (−4.15 μmol/L; 95% CI: −0.49, −7.81 μmol/L; P = 0 …
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NJ Timpson, NG Forouhi, MJ Brion, RM Harbord… - The American journal of clinical nutrition, 2010
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