作者
Rachel M Freathy, Gbenga R Kazeem, Richard W Morris, Paul CD Johnson, Lavinia Paternoster, Shah Ebrahim, Andrew T Hattersley, Anita Hill, Aroon D Hingorani, Claus Holst, Barbara J Jefferis, Sofia II Kring, Vincent Mooser, Sandosh Padmanabhan, Martin Preisig, Susan M Ring, Naveed Sattar, Mark N Upton, Peter Vollenweider, Gerard Waeber, Thorkild IA Sørensen, Timothy M Frayling, Graham Watt, Debbie A Lawlor, Peter H Whincup, Federica Tozzi, George Davey Smith, Marcus Munafò
发表日期
2011/12/1
期刊
International Journal of Epidemiology
卷号
40
期号
6
页码范围
1617-1628
出版商
Oxford University Press
简介
Background Cigarette smoking is associated with lower body mass index (BMI), and a commonly cited reason for unwillingness to quit smoking is a concern about weight gain. Common variation in the CHRNA5-CHRNA3-CHRNB4 gene region (chromosome 15q25) is robustly associated with smoking quantity in smokers, but its association with BMI is unknown. We hypothesized that genotype would accurately reflect smoking exposure and that, if smoking were causally related to weight, it would be associated with BMI in smokers, but not in never smokers.
Methods We stratified nine European study samples by smoking status and, in each stratum, analysed the association between genotype of the 15q25 SNP, rs1051730, and BMI. We meta-analysed the results (n = 24 198) and then tested for a genotype × smoking status interaction.
Results There was no evidence of …
学术搜索中的文章
Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index
RM Freathy, GR Kazeem, RW Morris, PCD Johnson… - International journal of epidemiology, 2011