作者
Jason A Chou, Elani Streja, Danh V Nguyen, Connie M Rhee, Yoshitsugu Obi, Jula K Inrig, Alpesh Amin, Csaba P Kovesdy, John J Sim, Kamyar Kalantar-Zadeh
发表日期
2018/1/1
期刊
Nephrology Dialysis Transplantation
卷号
33
期号
1
页码范围
149-159
出版商
Oxford University Press
简介
Background
Intradialytic hypotension (IDH) occurs frequently in maintenance hemodialysis (HD) patients and may be associated with higher mortality. We hypothesize that nadir intradialytic systolic blood pressure (niSBP) is inversely related to death risk while iSBP change (Δ) and IDH frequency are incrementally associated with all-cause mortality.
Methods
In a US-based cohort of 112 013 incident HD patients over a 5-year period (2007–11), using niSBP, ΔiSBP (pre-HD SBP minus niSBP) and IDH frequency (proportion of HD treatments with niSBP <90 mmHg) within the first 91 days of HD, we examined mortality-predictability at 1, 2 and 5 years using Cox models and restricted cubic splines adjusted for case-mix, comorbidities and laboratory covariates.
Results
We observed that niSBP of <90 and ≥140 mmHg had a 5-year mortality hazard ratio (HR …
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JA Chou, E Streja, DV Nguyen, CM Rhee, Y Obi… - Nephrology Dialysis Transplantation, 2018