作者
Chikako Nakano, Takayuki Hamano, Naohiko Fujii, Yoshitsugu Obi, Isao Matsui, Kodo Tomida, Satoshi Mikami, Kazunori Inoue, Akihiro Shimomura, Yasuyuki Nagasawa, Noriyuki Okada, Yoshiharu Tsubakihara, Hiromi Rakugi, Yoshitaka Isaka
发表日期
2012/6/1
期刊
Bone
卷号
50
期号
6
页码范围
1266-1274
出版商
Elsevier
简介
PURPOSE
Low 25-hydroxyvitamin D (25D), increased levels of fibroblast growth factor 23 (FGF23), parathyroid hormone (PTH), and alkaline phosphatase (ALP) were reported to be risk factors for mortality in chronic kidney disease (CKD). However, the independent associations of these factors with cardiovascular disease (CVD), the leading cause of death among CKD patients, remain unclear. Our purpose was to identify which of these factors predict incident CVD in CKD.
METHODS
In this prospective cohort study, we enrolled 738 predialysis outpatients in the two nephrology departments. We employed Cox proportional hazards analyses to elucidate predictors of the endpoint, defined as fatal or non-fatal cardiovascular event requiring hospitalization. Multiple imputation was performed for missing values.
RESULTS
Mean estimated glomerular filtration rate (eGFR) was 35mL/min/1.73m2. During a median …
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C Nakano, T Hamano, N Fujii, Y Obi, I Matsui… - Bone, 2012