作者
Lorelei A Mucci, Jacob B Hjelmborg, Jennifer R Harris, Kamila Czene, David J Havelick, Thomas Scheike, Rebecca E Graff, Klaus Holst, Sören Möller, Robert H Unger, Christina McIntosh, Elizabeth Nuttall, Ingunn Brandt, Kathryn L Penney, Mikael Hartman, Peter Kraft, Giovanni Parmigiani, Kaare Christensen, Markku Koskenvuo, Niels V Holm, Kauko Heikkilä, Eero Pukkala, Axel Skytthe, Hans-Olov Adami, Jaakko Kaprio
发表日期
2016/1/5
期刊
Jama
卷号
315
期号
1
页码范围
68-76
出版商
American Medical Association
简介
Importance
Estimates of familial cancer risk from population-based studies are essential components of cancer risk prediction.
Objective
To estimate familial risk and heritability of cancer types in a large twin cohort.
Design, Setting, and Participants
Prospective study of 80 309 monozygotic and 123 382 same-sex dizygotic twin individuals (N = 203 691) within the population-based registers of Denmark, Finland, Norway, and Sweden. Twins were followed up a median of 32 years between 1943 and 2010. There were 50 990 individuals who died of any cause, and 3804 who emigrated and were lost to follow-up.
Exposures
Shared environmental and heritable risk factors among pairs of twins.
Main Outcomes and Measures
The main outcome was incident cancer. Time-to-event analyses were used to estimate familial risk (risk of cancer in an individual given a twin’s development of cancer) and heritability (proportion …
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