作者
C‐E Fernandez‐García, Elena Burillo, Jes S Lindholt, Diego Martinez‐Lopez, Katrine Pilely, Carla Mazzeo, J‐B Michel, Jesus Egido, Peter Garred, Luis M Blanco‐Colio, Jose L Martin‐Ventura
发表日期
2017/3/1
期刊
Journal of Thrombosis and Haemostasis
卷号
15
期号
3
页码范围
575-585
出版商
Elsevier
简介
Essentials
- •Abdominal aortic aneurysm (AAA) is asymptomatic and its evolution unpredictable.
- •To find novel potential biomarkers of AAA, microvesicles are an excellent source of biomarkers.
- •Ficolin‐3 is increased in microvesicles obtained from activated platelets and AAA tissue.
- •Increased ficolin‐3 plasma levels are associated with AAA presence and progression.
Summary: Background
Abdominal aortic aneurysm (AAA) patients are usually asymptomatic and AAA evolution is unpredictable. Ficolin‐3, mainly synthesized by the liver, is a molecule of the lectin complement‐activation pathway involved in AAA pathophysiology.
Objectives
To define extra‐hepatic sources of ficolin‐3 in AAA and investigate the role of ficolin‐3 as a biomarker of the presence and progression of AAA.
Methods
Microvesicles (exosomes and microparticles) were isolated from culture‐conditioned medium of ADP‐activated platelets, as well as …
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CE Fernandez‐García, E Burillo, JS Lindholt… - Journal of Thrombosis and Haemostasis, 2017