作者
Vlad C Sandulache, Thomas J Ow, Curtis R Pickering, Mitchell J Frederick, Ge Zhou, Izabela Fokt, Melinda Davis‐Malesevich, Waldemar Priebe, Jeffrey N Myers
发表日期
2011/7/1
期刊
Cancer
卷号
117
期号
13
页码范围
2926-2938
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
BACKGROUND
Tumor metabolism is an essential contributor to disease progression and response to treatment. An understanding of the metabolic phenotype of head and neck squamous cell carcinoma (HNSCC) will allow the development of appropriate antimetabolic strategies for this tumor type.
METHODS
A panel of 15 HNSCC cell lines was assayed for glucose and glutamine dependence and sensitivity to metabolic inhibitors. In addition, broad‐spectrum metabolomic analysis using mass spectrometry/liquid chromatography was combined with individual measurements of reducing potential, adenosine triphosphate, and lactate production to characterize cellular metabolic phenotypes.
RESULTS
HNSCC energy and reducing potential levels closely mirrored extracellular glucose concentrations. Glucose starvation induced cell death despite the activation of secondary energetic pathways. Conversely …
学术搜索中的文章
VC Sandulache, TJ Ow, CR Pickering, MJ Frederick… - Cancer, 2011