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Industry 4.0 is based on the digitization of manufacturing industries and has raised the prospect for substantial improvements in productivity, quality, and customer satisfaction. This digital transformation not only affects the way products are manufactured but also creates new opportunities for the design of products, processes, services, and systems. Unlike traditional design practices based on system-centric concepts, design for these new opportunities requires a holistic view of the human (stakeholder), artefact (product), and process (realization) dimensions of the design problem. In this paper we envision a “human-cyber-physical view of the systems realization ecosystem,” termed “Design Engineering 4.0 (DE4.0),” to reconceptualize how cyber and physical technologies can be seamlessly integrated to identify and fulfil customer needs and garner the benefits of Industry 4.0. In this paper, we review the …