作者
Eric Jones, Peter Roemer, Mrinal Raghupathi, Stephen Pankavich
发表日期
2014
期刊
SIAM Undergraduate Research Online
卷号
7
页码范围
89-106
简介
Mathematical modeling of biological systems is crucial to effectively and efficiently developing treatments for medical conditions that plague humanity. Often, systems of ordinary differential equations are a traditional tool used to describe the spread of disease within the body. We consider the dynamics of the Human Immunodeficiency Virus (HIV) in vivo during the initial stage of infection. In particular, we examine the well-known three-component model and prove the existence, uniqueness, and boundedness of solutions. Furthermore, we prove that solutions remain biologically meaningful, i.e., are positivity preserving, and perform a thorough, local stability analysis for the equilibrium states of the system. Finally, we incorporate random coefficients within the model and obtain numerical results to predict the probability of infection given the transmission of the virus to a new individual.
引用总数
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学术搜索中的文章
E Jones, P Roemer, M Raghupathi, S Pankavich - arXiv preprint arXiv:1312.3671, 2013