作者
Gregory K Bergey, Martha J Morrell, Eli M Mizrahi, Alica Goldman, David King-Stephens, Dileep Nair, Shraddha Srinivasan, Barbara Jobst, Robert E Gross, Donald C Shields, Gregory Barkley, Vicenta Salanova, Piotr Olejniczak, Andrew Cole, Sydney S Cash, Katherine Noe, Robert Wharen, Gregory Worrell, Anthony M Murro, Jonathan Edwards, Michael Duchowny, David Spencer, Michael Smith, Eric Geller, Ryder Gwinn, Christopher Skidmore, Stephan Eisenschenk, Michel Berg, Christianne Heck, Paul Van Ness, Nathan Fountain, Paul Rutecki, Andrew Massey, Cormac O'Donovan, Douglas Labar, Robert B Duckrow, Lawrence J Hirsch, Tracy Courtney, Felice T Sun, Cairn G Seale
发表日期
2015/2/24
期刊
Neurology
卷号
84
期号
8
页码范围
810-817
出版商
Lippincott Williams & Wilkins
简介
Objective
The long-term efficacy and safety of responsive direct neurostimulation was assessed in adults with medically refractory partial onset seizures.
Methods
All participants were treated with a cranially implanted responsive neurostimulator that delivers stimulation to 1 or 2 seizure foci via chronically implanted electrodes when specific electrocorticographic patterns are detected (RNS System). Participants had completed a 2-year primarily open-label safety study (n = 65) or a 2-year randomized blinded controlled safety and efficacy study (n = 191); 230 participants transitioned into an ongoing 7-year study to assess safety and efficacy.
Results
The average participant was 34 (±11.4) years old with epilepsy for 19.6 (±11.4) years. The median preimplant frequency of disabling partial or generalized tonic-clonic seizures was 10.2 seizures a month. The median percent seizure reduction in the randomized blinded …
学术搜索中的文章
GK Bergey, MJ Morrell, EM Mizrahi, A Goldman… - Neurology, 2015
