作者
TDM Hill, M‐G Cascio, Barbara Romano, Marnie Duncan, RG Pertwee, CM Williams, BJ Whalley, AJ Hill
发表日期
2013/10
期刊
British journal of pharmacology
卷号
170
期号
3
页码范围
679-692
简介
Background and Purpose
Epilepsy is the most prevalent neurological disease and is characterized by recurrent seizures. Here, we investigate (i) the anticonvulsant profiles of cannabis‐derived botanical drug substances (BDSs) rich in cannabidivarin (CBDV) and containing cannabidiol (CBD) in acute in vivo seizure models and (ii) the binding of CBDV BDSs and their components at cannabinoid CB1 receptors.
Experimental Approach
The anticonvulsant profiles of two CBDV BDSs (50–422 mg·kg−1) were evaluated in three animal models of acute seizure. Purified CBDV and CBD were also evaluated in an isobolographic study to evaluate potential pharmacological interactions. CBDV BDS effects on motor function were also investigated using static beam and grip strength assays. Binding of CBDV BDSs to cannabinoid CB1 receptors was evaluated using displacement binding assays.
Key Results
CBDV …
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TDM Hill, MG Cascio, B Romano, M Duncan… - British journal of pharmacology, 2013