作者
K Juston Osborne, Wendy Zhang, Jaclyn Farrens, McKena Geiger, Brian Kraus, James Glazer, Robin Nusslock, Emily S Kappenman, Vijay A Mittal
发表日期
2022/5
期刊
Journal of psychopathology and clinical science
卷号
131
期号
4
页码范围
375
出版商
American Psychological Association
简介
Motor abnormalities are a core feature of psychotic disorders observed from the premorbid period through chronic illness, suggesting motor dysfunction may reflect the pathophysiology of psychosis. Electrophysiology research in schizophrenia suggests impaired motor activation and preparation may underlie these motor abnormalities. Despite behavioral studies suggesting similar motor dysfunction in those at clinical high-risk (CHR) for psychosis, there have been no studies examining neural mechanisms of motor dysfunction in the CHR period, where research can inform pathophysiological and risk models. The present study used the lateralized readiness potential (LRP), an event-related potential index of motor activation and preparation, to examine mechanisms of motor dysfunction in 42 CHR and 41 control participants (N= 83, 56% female). Response competition was manipulated to determine whether …
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