作者
Bruce S Cushing, Adam Perry, Sergei Musatov, Sonoko Ogawa, Eros Papademetriou
发表日期
2008/10/8
期刊
Journal of Neuroscience
卷号
28
期号
41
页码范围
10399-10403
出版商
Society for Neuroscience
简介
Studies using estrogen receptor α (ERα) knock-out mice indicate that ERα masculinizes male behavior. Recent studies of ERα and male prosocial behavior have shown an inverse relationship between ERα expression in regions of the brain that regulate social behavior, including the medial amygdala (MeA), and the expression of male prosocial behavior. These studies have lead to the hypothesis that low levels of ERα are necessary to “permit” the expression of high levels of male prosocial behavior. To test this, viral vectors were used to enhance ERα in male prairie voles (Microtus ochrogaster), which display high levels of prosocial behavior and low levels of MeA ERα. Adult male prairie voles were transfected with ERα in the MeA (MeA-ERα) or the caudate–putamen (ERα control) or luciferase (MeA-site-specific control), and 3 weeks later tested for spontaneous alloparental behavior and partner preference …
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BS Cushing, A Perry, S Musatov, S Ogawa… - Journal of Neuroscience, 2008