作者
Steven YC Tong, Jocelyn Mora, Asha C Bowen, Matthew P Cheng, Nick Daneman, Anna L Goodman, George S Heriot, Todd C Lee, Roger J Lewis, David C Lye, Robert K Mahar, Julie Marsh, Anna McGlothlin, Zoe McQuilten, Susan C Morpeth, David L Paterson, David J Price, Jason A Roberts, J Owen Robinson, Sebastiaan J van Hal, Genevieve Walls, Steve A Webb, Lyn Whiteway, Dafna Yahav, Joshua S Davis
发表日期
2022/12/1
来源
Clinical Infectious Diseases
卷号
75
期号
11
页码范围
2027-2034
出版商
Oxford University Press
简介
Staphylococcus aureus bloodstream (SAB) infection is a common and severe infectious disease, with a 90-day mortality of 15%–30%. Despite this, <3000 people have been randomized into clinical trials of treatments for SAB infection. The limited evidence base partly results from clinical trials for SAB infections being difficult to complete at scale using traditional clinical trial methods. Here we provide the rationale and framework for an adaptive platform trial applied to SAB infections. We detail the design features of the Staphylococcus aureus Network Adaptive Platform (SNAP) trial that will enable multiple questions to be answered as efficiently as possible. The SNAP trial commenced enrolling patients across multiple countries in 2022 with an estimated target sample size of 7000 participants. This approach may serve as an exemplar to increase efficiency of clinical trials for other infectious disease …
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SYC Tong, J Mora, AC Bowen, MP Cheng, N Daneman… - Clinical Infectious Diseases, 2022