查看文章

Globally, the incidence of diabetes continues to rise and significant resources are spent on its prevention and treatment. However, the pathogenesis of this disease has yet to be fully understood or explained. Current research indicates that diabetes, especially type 2 diabetes, is highly correlated to an abnormal intestinal microbiota. Bacteria in the gut are essential for numerous metabolic processes including the production of hormones and neurotransmitters and the biosynthesis of vitamins and amino acids. Several studies have shown that gut bacteria play a significant role in controlling type 2 diabetes. The following research aims to show how gut bacteria can be manipulated to improve outcomes in managing diabetes mellitus. This review of research was conducted to determine the role of the gut bacteria in modulating metabolic health and insulin resistance. Various articles, journals, and books were reviewed, and a meta-analysis of the results conducted. From this review of literature, it was noted that alteration of gut bacteria to a more natural balance might reduce oxidative stress on the pancreas and enhance cell permeability glucose uptake. However, an inimical alteration in gut bacteria can spur the overgrowth of certain bacterial species that contribute to diabetes. Thus, it is advised to consume requisite dietary fibers to maintain or restore the gut microbiome in promoting healthy body weight and blood glucose level.

Preface Diabetes mellitus (DM) affects approximately 150 million people worldwide according to the data from the World Health Organization (WHO)[1]. The number of people affected by DM is likely to double by 2025 due to …