作者
Ramin Akhi, Chunguang Wang, Antti E Nissinen, Jari Kankaanpää, Risto Bloigu, Susanna Paju, Päivi Mäntylä, Kåre Buhlin, Juha Sinisalo, Pirkko J Pussinen, Sohvi Hörkkö
发表日期
2019/3
期刊
Journal of Dental Research
卷号
98
期号
3
页码范围
296-303
出版商
SAGE Publications
简介
A large body of literature has established the link between periodontal disease and cardiovascular disease. Oxidized low-density lipoproteins (OxLDLs) have a crucial role in atherosclerosis progression through initiation of immunological response. Monoclonal IgM antibodies to malondialdehyde-modified low-density lipoprotein (MDA-LDL) and to malondialdehyde acetaldehyde–modified low-density lipoprotein (MAA-LDL) have been shown to cross-react with the key virulence factors of periodontal pathogens Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans. We have previously shown that salivary IgA antibodies to MAA-LDL cross-react with P. gingivalis in healthy humans. In this study, we aim to assess whether oral mucosal immune response represented by salivary IgA to MAA-LDL and oral pathogens is associated with coronary artery disease (CAD). Also, the molecular mimicry through …
学术搜索中的文章
R Akhi, C Wang, AE Nissinen, J Kankaanpää, R Bloigu… - Journal of Dental Research, 2019