作者
Martine Vrijheid, Rémy Slama, Oliver Robinson, Leda Chatzi, Muireann Coen, Peter Van den Hazel, Cathrine Thomsen, John Wright, Toby J Athersuch, Narcis Avellana, Xavier Basagaña, Celine Brochot, Luca Bucchini, Mariona Bustamante, Angel Carracedo, Maribel Casas, Xavier Estivill, Lesley Fairley, Diana van Gent, Juan R Gonzalez, Berit Granum, Regina Gražulevicˇiene, Kristine B Gutzkow, Jordi Julvez, Hector C Keun, Manolis Kogevinas, Rosemary RC McEachan, Helle Margrete Meltzer, Eduard Sabidó, Per E Schwarze, Valérie Siroux, Jordi Sunyer, Elizabeth J Want, Florence Zeman, Mark J Nieuwenhuijsen
发表日期
2014/6
来源
Environmental health perspectives
卷号
122
期号
6
页码范围
535-544
出版商
NLM-Export
简介
Background: Developmental periods in early life may be particularly vulnerable to impacts of environmental exposures. Human research on this topic has generally focused on single exposure–health effect relationships. The “exposome” concept encompasses the totality of exposures from conception onward, complementing the genome.
Objectives: The Human Early-Life Exposome (HELIX) project is a new collaborative research project that aims to implement novel exposure assessment and biomarker methods to characterize early-life exposure to multiple environmental factors and associate these with omics biomarkers and child health outcomes, thus characterizing the “early-life exposome.” Here we describe the general design of the project.
Methods: In six existing birth cohort studies in Europe, HELIX will estimate prenatal and postnatal exposure to a broad range of chemical and physical exposures. Exposure …
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M Vrijheid, R Slama, O Robinson, L Chatzi, M Coen… - Environmental health perspectives, 2014