查看文章

Neurol Clin 33 (2015) 361–380 http://dx. doi. org/10.1016/j. ncl. 2014.12. 003 neurologic. theclinics. com 0733-8619/15/$–see front matter© 2015 Elsevier Inc. All rights reserved. are reasonable arguments physiologically to support both lowering BP and refraining from early BP reduction (permissive hypertension). The rationale for lowering BP is to reduce or prevent cerebral edema and limit hemorrhagic transformation of the infarct. Alternatively, the concern with lowering BP in AIS is the expansion of the central ischemic core by worsening hypoperfusion within the ischemic penumbra, because this area may have disrupted cerebral autoregulation. The key clinical questions that are reviewed based on the currently available evidence include the following:(1) When should antihypertensive therapy be started following AIS?(2) How fast and what goal BP should be targeted?(3) Which is the best antihypertensive …