作者
Cynthia Villarreal-Garza, Juan Enrique Bargallo-Rocha, Enrique Soto-Perez-de-Celis, Federico Lasa-Gonsebatt, Claudia Arce-Salinas, Fernando Lara-Medina, Nancy Reynoso-Noverón, Juan Matus-Santos, Paula Cabrera, Alberto Alvarado-Miranda, Alejandro Mohar
发表日期
2016/6
期刊
Breast cancer research and treatment
卷号
157
页码范围
385-394
出版商
Springer US
简介
Breast cancer in young women has been shown to have an aggressive behavior and worse prognosis. Studies evaluating young women enrolled in clinical trials of neoadjuvant chemotherapy have shown that age is a determinant factor in the achievement of a pathological complete response (pCR). In this study, we sought to analyze the outcomes of young patients treated with neoadjuvant chemotherapy at a single institution. 1639 patients treated with neoadjuvant chemotherapy were included. 316 patients ≤40 years were compared with 1323 patients aged >40 years regarding the achievement of a pCR (defined as no invasive residual tumor in the breast or lymph nodes). Disease-free survival (DFS) and overall survival were compared between groups according to pCR status and subtype, defined by hormone receptor (HR) and HER2 status. Young women were more likely to have a pCR than their …
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C Villarreal-Garza, JE Bargallo-Rocha… - Breast cancer research and treatment, 2016