作者
Yu Xie, Catherine Oppenheim, Francis Guillemin, Vincent Gautheron, Benjamin Gory, Hélène Raoult, Sébastien Soize, Jacques Felblinger, Gabriela Hossu, Serge Bracard, THRACE investigators
发表日期
2018/1
期刊
Annals of neurology
卷号
83
期号
1
页码范围
178-185
简介
Objective
We aimed to characterize the association between pretreatment lesional volume measured on diffusion‐weighted images and functional outcome, and estimate the impact on thrombectomy efficacy for ischemic stroke with anterior proximal intracranial arterial occlusion.
Methods
Anterior circulation ischemic stroke patients who had pretreatment diffusion‐weighted imaging in the THRACE study were included. Lesional volume was semiautomatically segmented. Logistic regression was applied to model clinical outcome as a function of lesional volume. Outcomes included functional independence (modified Rankin Scale [mRS] 0–2), degree of disability (ordinal mRS 0–6), and mortality at 3 months.
Results
Of 298 included patients, with median lesional volume 17.2ml (interquartile range [IQR], 9.2–51.8) and median mRS 2 (IQR, 1–4), 51.0% achieved functional independence. Increased lesional volume …
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Y Xie, C Oppenheim, F Guillemin, V Gautheron, B Gory… - Annals of neurology, 2018