作者
Anne-Laure Constant Dit Beaufils, Olivier Huttin, Antoine Jobbe-Duval, Thomas Senage, Laura Filippetti, Nicolas Piriou, Caroline Cueff, Clément Venner, Damien Mandry, Jean-Marc Sellal, Solena Le Scouarnec, Romain Capoulade, Marie Marrec, Aurélie Thollet, Marine Beaumont, Gabriella Hossu, Claire Toquet, Jean-Baptiste Gourraud, Jean-Noël Trochu, Karine Warin-Fresse, Pierre-Yves Marie, Jean-Jacques Schott, Jean-Christian Roussel, Jean-Michel Serfaty, Christine Selton-Suty, Thierry Le Tourneau
发表日期
2021/5/4
期刊
Circulation
卷号
143
期号
18
页码范围
1763-1774
出版商
Lippincott Williams & Wilkins
简介
Background
Mitral valve prolapse (MVP) is a frequent disease that can be complicated by mitral regurgitation (MR), heart failure, arterial embolism, rhythm disorders, and death. Left ventricular (LV) replacement myocardial fibrosis, a marker of maladaptive remodeling, has been described in patients with MVP, but the implications of this finding remain scarcely explored. We aimed at assessing the prevalence, pathophysiological and prognostic significance of LV replacement myocardial fibrosis through late gadolinium enhancement (LGE) by cardiac magnetic resonance in patients with MVP.
Methods
Four hundred patients (53±15 years of age, 55% male) with MVP (trace to severe MR by echocardiography) from 2 centers, who underwent a comprehensive echocardiography and LGE cardiac magnetic resonance, were included. Correlates of replacement myocardial fibrosis (LGE+), influence of MR degree, and …
学术搜索中的文章
AL Constant Dit Beaufils, O Huttin, A Jobbe-Duval… - Circulation, 2021