作者
Imad Derraz, Romain Bourcier, Marc Soudant, Sébastien Soize, Wagih Ben Hassen, Gabriella Hossu, Frederic Clarencon, Anne Laure Derelle, Marie Tisserand, Helene Raoult, Laurence Legrand, Serge Bracard, Catherine Oppenheim, Olivier Naggara
发表日期
2019/1
期刊
Journal of Stroke
卷号
21
期号
1
页码范围
91
出版商
Korean Stroke Society
简介
Background and Purpose
A long clot, defined by a low (0-6) clot burden score (CBS) assessed by T2*-MR sequence, is associated with worse clinical outcome after intravenous thrombolysis (IVT) for acute ischemic stroke than is a small clot (CBS, 7-10). The added benefit of mechanical thrombectomy (MT) might be higher in patients with long clot. The aim of this pre-specified post hoc analysis of the THRombectomie des Artères CErebrales (THRACE) trial was to assess the association between T2*-CBS, successful recanalization and clinical outcome.
Methods
Of 414 patients randomized in the THRACE trial, 281 patients were included in this analysis. Associations between T2*-CBS and clinical outcome on the modified Rankin Scale (mRS) at 3 months were tested.
Results
High T2*-CBS, ie, small clot, was associated with a shift toward better outcome on the mRS; proportional odds ratio (POR) per point CBS was 1 …
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I Derraz, R Bourcier, M Soudant, S Soize, WB Hassen… - Journal of Stroke, 2019