查看文章

Objective

Prior studies suggest polymorphisms in inflammatory genes are associated with risk for preterm birth (PTB). Nucleotide polymorphisms (SNPs) in tumor necrosis factor alpha (TNF) were more common in women with PTB. We tested the hypothesis that SNPs in the TNF gene interact with bacterial vaginosis (BV) infection persistence or clearance and mediate the risk for PTB.

Study Design

A secondary analysis of pregnancies enrolled in a multicenter RCT investigating periodontal disease and PTB. 8 TNF SNPs were identified via dbSNP, Bio-Carta, and KEGG. BV diagnosis (Nugent score) was collected at enrollment (6-20 weeks) and in the third trimester. Change in BV status was defined as “new onset”,“cleared” or “persistent” at the second time point. Due to SNP variability by race this analysis was limited to Black women. Univariable and logistic regression models tested interactions between change in BV …