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Ranibizumab is a recombinant VEGF‐A antibody used in clinics for the treatment of wet form of age‐related macular degeneration. It is intraviterally administered to ocular compartments and it needs frequent injections. However, intraviteral administration could cause side complications as well as patient discomfort. These necessitate alternative treatment strategies based on relatively noninvasive ranibizumab delivery that is more effective and sustainable in the eye vitreous than the current clinical regimen. Herein, we developed self‐assembled peptide microgels from peptide amphiphile molecules to sustainably release ranibizumab from these microgels at high local dose. Peptide amphiphile molecules, which come together by themselves to form supramolecular filaments, can form gels only in the presence of electrolyte without the need for any agent and provide ease of use compared to polymeric materials …