作者
Shaobo Mo, Weixing Dai, Hui Wang, Xiaoliang Lan, Chengcheng Ma, Zhixi Su, Wenqiang Xiang, Lingyu Han, Wenqin Luo, Long Zhang, Renjie Wang, Yaodong Zhang, Wenming Zhang, Lin Yang, Renquan Lu, Lin Guo, Ying Zheng, Mingzhu Huang, Ye Xu, Li Liang, Sanjun Cai, Guoxiang Cai
发表日期
2023/1/1
期刊
EClinicalMedicine
卷号
55
出版商
Elsevier
简介
Background
Early detection and prognosis prediction of colorectal cancer (CRC) can significantly reduce CRC-related mortality. Recently, circulating tumour DNA (ctDNA) methylation has shown good application foreground in the early detection and prognosis prediction of multiple tumours.
Methods
This multicentre cohort study evaluated ctDNA methylation haplotype patterns based on archived plasma samples (collected between 2010 and 2018) from 1138 individuals at two medical centres: Fudan University Shanghai Cancer Center (Shanghai, China) and Southern Medical University Nanfang Hospital (Guangzhou, Guangdong, China), including 366 healthy individuals, 182 patients with advanced adenoma (AA), and 590 patients with CRC. Samples were processed using the ColonES assay, a targeted bisulfite sequencing method that detects ctDNA methylation haplotype patterns in 191 genomic regions …
学术搜索中的文章
S Mo, W Dai, H Wang, X Lan, C Ma, Z Su, W Xiang… - EClinicalMedicine, 2023