作者
Gerhard Sommer, Daniel Ch Haspinger, Michaela Andrä, Michael Sacherer, Christian Viertler, Peter Regitnig, Gerhard A Holzapfel
发表日期
2015/10
期刊
Annals of biomedical engineering
卷号
43
页码范围
2334-2348
出版商
Springer US
简介
One goal of cardiac research is to perform numerical simulations to describe/reproduce the mechanoelectrical function of the human myocardium in health and disease. Such simulations are based on a complex combination of mathematical models describing the passive mechanical behavior of the myocardium and its electrophysiology, i.e., the activation of cardiac muscle cells. The problem in developing adequate constitutive models is the shortage of experimental data suitable for detailed parameter estimation in specific functional forms. A combination of shear and biaxial extension tests with different loading protocols on different specimen orientations is necessary to capture adequately the direction-dependent (orthotropic) response of the myocardium. In most experimental animal studies, where planar biaxial extension tests on the myocardium have been conducted, the generated shear stresses …
引用总数
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