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Carotid artery dissections can be triggered by several factors. The underlying biomechanical phenomena and properties are unclear. This study investigates the dissection properties of 62 human carotid bifurcations using two experimental methods: direct tension and peeling tests. Direct tension tests study the mechanical strength of the tissue components in radial direction, while peeling tests quantify the fracture energy required to propagate a dissection in a tissue. Results show that the interface between the healthy adventitia and media has the highest radial failure stress (132 ± 20 kPa, mean ± SD, n = 25), whereas the lowest value occurs between the diseased intima and media (104 ± 24 kPa, n = 18). The radial tissue strength at the bifurcation is the highest compared with locations that are away from the central region of the bifurcation. Force/width values required to separate the individual layers and …