作者
Katharina Kircanski, Lauren K White, Wan-Ling Tseng, Jillian Lee Wiggins, Heather R Frank, Stefanie Sequeira, Susan Zhang, Rany Abend, Kenneth E Towbin, Argyris Stringaris, Daniel S Pine, Ellen Leibenluft, Melissa A Brotman
发表日期
2018/6/1
期刊
JAMA psychiatry
卷号
75
期号
6
页码范围
631-639
出版商
American Medical Association
简介
Importance
Comorbidity is ubiquitous in psychiatry, but it is unclear how to differentiate neural mechanisms of co-occurring symptoms. Pediatric irritability and anxiety symptoms are prevalent and frequently co-occur. Threat orienting is pertinent to both phenotypes and is an ideal context in which to examine their unique and common neural mechanisms.
Objectives
To decompose the unique and shared variances of pediatric irritability and anxiety symptoms and to determine neural correlates of these differentiated phenotypes during threat orienting.
Design, Setting, and Participants
This investigation was a cross-sectional functional magnetic resonance imaging study. The setting was a research clinic at the National Institute of Mental Health. Participants were youth aged 8 to 18 years spanning multiple diagnostic categories (141 youth with disruptive mood dysregulation disorder, anxiety disorder, and/or attention …
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