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Introduction: The H2FPEF score is a recommended tool for estimating the likelihood of heart failure with preserved ejection fraction (HFpEF) in cases of unexplained dyspnea. Limited data is available regarding its prognostic ability. This restrospective study aimed to assess the prognostic value of the H2FPEF score for adverse cardiovascular outcomes.

Methods: 532 patients [age 69±6 years, 57% female, and ejection fraction 61±5% (all >50%)] with suspected symptoms of heart failure (HF) referred for exercise echocardiography were included. H2FPEF score was calculated based on: BMI >30 kg/m2 (2 points), atrial fibrillation (3 points), age >60 years (1 point), use of ≥2 hypertension drugs (1 point), E/e’ ratio >9 (1 point), and pulmonary systolic pressure >35 mmHg (1 point). Comparisons were made for death and HF hospitalization.

Results: During a median follow-up of 3.8 years, 13 patients died, 35 had HF …