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Duchenne Muscular Dystrophy (DMD) is a fatal X‐linked genetic disease that is hallmarked by progressive muscle weakness and degeneration. DMD is the most common form of all the muscular dystrophies, affecting 1:5,000 live male births. DMD is caused by mutations in the dystrophin gene, which ablate the expression of dystrophin resulting in compromised structural integrity of the muscle cell plasma membrane, also known as the sarcolemma. There is still an unmet need for novel therapies that address the underlying molecular cause of the disease. Previous work has shown that the tripartite motif protein 72/mitsugumin 53 (TRIM72/MG53) is critical for an effective cell membrane repair response after injury. Our previous results demonstrated that overexpressing TRIM72/MG53 or exogenously delivering recombinant human MG53 protein (rhMG53) can increase membrane repair capacity in many different cell …