作者
Bryan M Saltzman, Timothy Leroux, Maximilian A Meyer, Bryce A Basques, Jaskarndip Chahal, Bernard R Bach Jr, Adam B Yanke, Brian J Cole
发表日期
2017/9
来源
The American journal of sports medicine
卷号
45
期号
11
页码范围
2647-2653
出版商
SAGE Publications
简介
Background
Intra-articular normal saline (IA-NS) injections have been utilized as a placebo in a number of randomized controlled trials pertaining to the management of knee osteoarthritis (OA); however, it is believed that these “placebo” injections may have a therapeutic effect that has not been quantified in the literature.
Purpose
To (1) quantify the effect of IA-NS injections on patient-reported outcomes (PROs) and (2) compare postinjection PROs to established minimal clinically important difference (MCID) criteria to demonstrate a potential therapeutic effect.
Study Design
Meta-analysis.
Methods
A review was conducted to identify all randomized, placebo-controlled trials on injection therapy for knee OA between 2006 and 2016. Patient demographics and PROs before the injection and at 3 and 6 months after the injection were collected for patients in the IA-NS injection group in each study. A random-effects model …
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BM Saltzman, T Leroux, MA Meyer, BA Basques… - The American journal of sports medicine, 2017