作者
Diana J Kim, Nishita Singh, Luciana Catanese, Amy YX Yu, Andrew M Demchuk, Mar I Lloret-Villas, Yan Deschaintre, Shelagh B Coutts, Houman Khosravani, Ramana Appireddy, Francois Moreau, Gord Gubitz, Aleksander Tkach, Dar Dowlatshahi, George Medvedev, Jennifer Mandzia, Aleksandra Pikula, Jai Shankar, Heather Williams, Herbert Manosalva, Muzaffar Siddiqui, Atif Zafar, Oje Imoukhuede, Gary Hunter, Stephen Phillips, Michael D Hill, Alexandre Y Poppe, Ayoola Ademola, Michel Shamy, Fouzi Bala, Tolulope T Sajobi, Richard H Swartz, Mohammed A Almekhlafi, Bijoy K Menon, Thalia S Field
发表日期
2024/2
期刊
Stroke
卷号
55
期号
2
页码范围
288-295
出版商
Lippincott Williams & Wilkins
简介
BACKGROUND
Understanding sex differences in stroke care is important in reducing potential disparities. Our objective was to explore sex differences in workflow efficiency, treatment efficacy, and safety in the AcT trial (Alteplase Compared to Tenecteplase).
METHODS
AcT was a multicenter, registry-linked randomized noninferiority trial comparing tenecteplase (0.25 mg/kg) with alteplase (0.9 mg/kg) in acute ischemic stroke within 4.5 hours of onset. In this post hoc analysis, baseline characteristics, workflow times, successful reperfusion (extended Thrombolysis in Cerebral Infarction score ≥2b), symptomatic intracerebral hemorrhage, 90-day functional independence (modified Rankin Scale score, 0–1), and 90-day mortality were compared by sex. Mixed-effects regression analysis was used adjusting for age, stroke severity, and occlusion site for outcomes.
RESULTS
Of 1577 patients treated with intravenous …
学术搜索中的文章
DJ Kim, N Singh, L Catanese, AYX Yu, AM Demchuk… - Stroke, 2024