作者
Chun-Hao Kao, Chi-Hsiang Chung, Wu-Chien Chien, Daniel Hueng-Yuan Shen, Li-Fan Lin, Chuang-Hsin Chiu, Cheng-Yi Cheng, Chien-An Sun, Ping-Ying Chang
发表日期
2021/1
期刊
Journal of Clinical Medicine
卷号
10
期号
17
页码范围
4032
出版商
Multidisciplinary Digital Publishing Institute
简介
(1) Background: This study aimed to investigate the association between radioactive iodine (RAI) and long-term cardiovascular disease (CVD) morbidity/mortality in thyroid cancer. (2) Methods: The study was conducted using data from the Taiwan National Health Insurance Database during 2000–2015. Thyroid cancer patients aged ≥20 years were categorized into RAI (thyroidectomy with RAI) and non-RAI (thyroidectomy only) groups. The Cox proportional hazard regression model and Kaplan–Meier method were used for analysis. (3) Results: A total of 13,310 patients were included. Kaplan–Meier analysis demonstrated that the two groups had similar cumulative risks of CVD (log-rank p = 0.72) and CVD-specific mortality (log-rank p = 0.62). On Cox regression analysis of different RAI doses, the risk of CVD was higher in the cumulative dosage >3.7 GBq (hazard ratio = 1.69, 95% confidence interval = 1.24–2.40, p < 0.001). (4) Conclusions: RAI was not associated with an increased risk of CVD in thyroid cancer. However, CVD surveillance is indicated in the patients receiving the cumulative RAI dosage above 3.7 GBq.
学术搜索中的文章
CH Kao, CH Chung, WC Chien, DHY Shen, LF Lin… - Journal of Clinical Medicine, 2021