作者
Hai Pham, Mary Waterhouse, Catherine Baxter, Briony Duarte Romero, Donald SA McLeod, Bruce K Armstrong, Peter R Ebeling, Dallas R English, Gunter Hartel, Rachel L O’Connell, Jolieke C van der Pols, Alison J Venn, Penelope M Webb, David C Whiteman, Rachel E Neale
发表日期
2023/2/1
期刊
The American Journal of Clinical Nutrition
卷号
117
期号
2
页码范围
350-356
出版商
Elsevier
简介
Background
Evidence suggests that vitamin D influences the immune system. Recent studies indicate that vitamin D supplementation may reduce the severity of infections, but this has not been confirmed.
Objectives
The objective of this study was to assess the effect of vitamin D supplementation on hospitalization for infection.
Methods
The D-Health Trial was a randomized, double-blind, placebo-controlled trial of monthly 60,000 international units of vitamin D3 for 5 y among 21,315 Australians aged 60–84 y. Hospitalization for infection, ascertained through linkage with hospital admitted patient data, is a tertiary outcome of the trial. The primary outcome for this post-hoc analysis was hospitalization for any infection. Secondary outcomes were extended hospitalization for infection (length of stay >3 d and >6 d) and hospitalization for respiratory tract, skin, and gastrointestinal infections. We used negative binomial …
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H Pham, M Waterhouse, C Baxter, BD Romero… - The American Journal of Clinical Nutrition, 2023