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The present study evaluates the protective effects of an antioxidant‐rich extract of Spinacea oleracea (NAOE) in abnormalities associated with the metabolic syndrome (MetS) in rats. HPTLC of NAOE revealed the presence of 13 total antioxidants, 14 flavonoids, and 10 phenolic acids. Rats administered with fructose (20% w/v) in drinking water for 45 days to induce abnormalities of MetS received NAOE (200 and 400 mg/kg, po), the standard drug gemfibrozil (60 mg/kg, po), aerobic exercise (AE), and a combination of NAOE 400 mg/kg and AE (NAOEAE) daily for 45 days. All treatments significantly altered the lipid profile and attenuated the fructose‐elevated levels of uric acid, C‐reactive protein, homocysteine, and marker enzymes (AST, LDH, and CK‐MB) in serum and malondialdehyde in the heart and restored the fructose‐depleted levels of glutathione and antioxidant enzymes (superoxide dismutase …