作者
Susanna Zierler, Adriana Sumoza‐Toledo, Sayuri Suzuki, Fionán Ó Dúill, Lillia V Ryazanova, Reinhold Penner, Alexey G Ryazanov, Andrea Fleig
发表日期
2016/6/1
期刊
The Journal of physiology
卷号
594
期号
11
页码范围
2957-2970
简介
Key points
  • The Mg2+ and Ca2+ conducting transient receptor potential melastatin 7 (TRPM7) channel–enzyme (chanzyme) has been implicated in immune cell function.
  • Mice heterozygous for a TRPM7 kinase deletion are hyperallergic, while mice with a single point mutation at amino acid 1648, silencing kinase activity, are not.
  • As mast cell mediators trigger allergic reactions, we here determine the function of TRPM7 in mast cell degranulation and histamine release.
  • Our data establish that TRPM7 kinase activity regulates mast cell degranulation and release of histamine independently of TRPM7 channel function.
  • Our findings suggest a regulatory role of TRPM7 kinase activity on intracellular Ca2+ and extracellular Mg2+ sensitivity of mast cell degranulation.
Abstract
Transient receptor potential melastatin 7 (TRPM7) is a divalent ion channel with a C‐terminally located α‐kinase. Mice heterozygous for a TRPM7 …
引用总数
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学术搜索中的文章
S Zierler, A Sumoza‐Toledo, S Suzuki, FÓ Dúill… - The Journal of physiology, 2016