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A nongeometric, attenuation-correctedtechniqueto quantitateleftventricularvolumes using equilibrium radlonuclide angiography was validated Invitro and in vivo. Invitro experiments were performed to derive a linear attenuation coefficient, which was then employed inthe volume determinations using balloons Ina water bath. Good invitro correlationwas found between radionuclideand actual volumes (r= 0.99, p< 0.0001), over a wide range (5 to 400 ml). Invivo validationwas done by comparingthe nuclear technique to contrast angiography in 29 patients: Good correlations were found for end diastolic volume (r= 0.98), end-systolic volume (r= 0.95), stroke volume (r= 0.96), and ejection fraction (r= 0.85). When the conventional linear aftenuation coefficient was used, the radionuclide technique consistently overestimated volumes in vitro and Invivo. Afthough high intraobserver and Interobserver correlation coefficients …