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Copper-62-pyruvaldehyde bis (N4-methyl) thiosemicarbazone (PTSM) has been proposed as a generator-produced radiopharmaceutical for perfusion imaging using PET. Several clinical studies have demonstrated the ability of 62Cu-PTSM to quantitate myocardial and cerebral perfusion in humans. Because 62Cu-PTSM is genera tor-produced, it can be provided to clinical centers without cyclotron availability and, therefore, represents a cost-effective, practical PET perfusion tracer for clinical applications. To assess the safety, time-dependent biodistribution, and whole-body and organ-specific absorbed radiation dose estimates of this tracer, a Phase I study of 6ZCu-PTSM was performed using whole-body imaging with PET in

10 healthy volunteers and with the radiopharmaceutical delivered by a compact modular generator unit. Methods: Five male and five female subjects underwent a series of clinical tests and …