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To study the functional significance or transient coronary occlusion on systolic and diastolic left ventricular function relative to the anatomic site of occlusion, first-pass radionuclide angiography with a mobile multiwire gamma camera using tantalum-178 (dose activity ≤84 mCi/elution) was performed in 46 patients undergoing balloon coronary angioplasty. First-pass images were acquired immediately before angioplasty and during the last 30 s of a 60-s balloon inflation in 23 left anterior descending arteries, 18 right coronary arteries, 8 circumflex arteries and 5 diagonal coronary arteries.

Occlusion of the left anterior descending artery resulted in significant decreases in left ventricular ejection fraction (54.6 ± 12.7% to 32.3 ± 10.6%, p = 0.0001) and peak filling rate (2.48 ± 0.68 to 1.75 ± 0.64 end-diastolic volumes/s, p = 0.0001), accompanied by severe abnormalities in regional function and left ventricular dilation …