作者
Tatiana A Slastnikova, Andrey A Rosenkranz, Pavel V Gulak, Raymond M Schiffelers, Tatiana N Lupanova, Yuri V Khramtsov, Michael R Zalutsky, Alexander S Sobolev
发表日期
2012/2/2
期刊
International journal of nanomedicine
页码范围
467-482
出版商
Taylor & Francis
简介
Background
Modular nanotransporters (MNT) are recombinant multifunctional polypeptides created to exploit a cascade of cellular processes, initiated with membrane receptor recognition to deliver selective short-range and highly cytotoxic therapeutics to the cell nucleus. This research was designed for in vivo concept testing for this drug delivery platform using two modular nanotransporters, one targeted to the α-melanocyte-stimulating hormone (αMSH) receptor overexpressed on melanoma cells and the other to the epidermal growth factor (EGF) receptor overexpressed on several cancers, including glioblastoma, and head-and-neck and breast carcinoma cells.
Methods
In vivo targeting of the modular nanotransporter was determined by immuno-fluorescence confocal laser scanning microscopy and by accumulation of 125I-labeled modular nanotransporters. The in vivo therapeutic effects of the modular …
学术搜索中的文章
TA Slastnikova, AA Rosenkranz, PV Gulak… - International journal of nanomedicine, 2012