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According to the World Health Organization, the rate of people aged 60 or more is growing faster than any other age group in almost every country, and this trend is not going to change in a near future. Since senior citizens are at high risk of non communicable diseases requiring long-term care, this trend will challenge the sustainability of the entire health system. Pervasive computing can provide innovative methods and tools for early detecting the onset of health issues. In this paper we propose a novel method relying on medical models, provided by cognitive neuroscience researchers, describing abnormal activity routines that may indicate the onset of early symptoms of mild cognitive impairment. A non-intrusive sensor-based infrastructure acquires low-level data about the interaction of the individual with home appliances and furniture, as well as data from environmental sensors. Based on those data, a novel …