作者
Rebecca A Gladstone, Alan McNally, Anna K Pöntinen, Gerry Tonkin-Hill, John A Lees, Kusti Skytén, François Cléon, Martin OK Christensen, Bjørg C Haldorsen, Kristina K Bye, Karianne W Gammelsrud, Reidar Hjetland, Angela Kümmel, Hege E Larsen, Paul Christoffer Lindemann, Iren H Löhr, Åshild Marvik, Einar Nilsen, Marie T Noer, Gunnar S Simonsen, Martin Steinbakk, Ståle Tofteland, Marit Vattøy, Stephen D Bentley, Nicholas J Croucher, Julian Parkhill, Pål J Johnsen, Ørjan Samuelsen, Jukka Corander
发表日期
2021/7/1
期刊
The Lancet Microbe
卷号
2
期号
7
页码范围
e331-e341
出版商
Elsevier
简介
Background
The clonal diversity underpinning trends in multidrug resistant Escherichia coli causing bloodstream infections remains uncertain. We aimed to determine the contribution of individual clones to resistance over time, using large-scale genomics-based molecular epidemiology.
Methods
This was a longitudinal, E coli population, genomic, cohort study that sampled isolates from 22 512 E coli bloodstream infections included in the Norwegian surveillance programme on resistant microbes (NORM) from 2002 to 2017. 15 of 22 laboratories were able to share their isolates, and the first 22·5% of isolates from each year were requested. We used whole genome sequencing to infer the population structure (PopPUNK), and we investigated the clade composition of the dominant multidrug resistant clonal complex (CC)131 using genetic markers previously reported for sequence type (ST)131, effective population …
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RA Gladstone, A McNally, AK Pöntinen, G Tonkin-Hill… - The Lancet Microbe, 2021