作者
AC Martini, R Fernandez-Fernandez, S Tovar, VM Navarro, E Vigo, MJ Vazquez, JS Davies, NM Thompson, E Aguilar, L Pinilla, Timothy Wells, C Dieguez, M Tena-Sempere
发表日期
2006/5/1
期刊
Endocrinology
卷号
147
期号
5
页码范围
2374-2382
出版商
Endocrine Society
简介
Ghrelin, the endogenous ligand of GH secretagogue receptor type 1a, has emerged as pleiotropic modulator of diverse biological functions, including energy homeostasis and, recently, reproduction. Although inhibitory actions of ghrelin on LH secretion and puberty onset have been reported previously, the receptor mechanisms mediating these actions, and the potential gonadotropic effects of the unacylated isoform of ghrelin (UAG), remain unclear. In this work, the effects of single and repeated administration of ghrelin or UAG on LH secretion were compared in pubertal and adult male rats. In addition, the effects of ghrelin were assessed in models of transient or persistent hypergonadotropism. Daily injection of ghrelin or UAG throughout puberty similarly decreased LH levels and partially delayed balanopreputial separation. Likewise, chronic infusion of ghrelin or UAG to adult males resulted in significant …
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AC Martini, R Fernandez-Fernandez, S Tovar… - Endocrinology, 2006